反应详情

To a solution of (±)1-Amino-2-phenylethyl phosphonous acid (19) (70 mmol) in dioxane (200 mL) and aqueous 1 M NaOH (75 mL) at 0° C. was added dropwise benzyl chloroformate (20 mL). The pH of the solution during this addition was kept at 8-9 with the simultaneous addition of aqueous 1M NaOH (75 mL). The reaction mixture was stirred at room temperature for a further 16 hours and then was concentrated in vacuo to half volume. Washed with diethyl ether (2×75 mL) and then acidified to pH1 with the addition of concentrated aqueous hydrochloric acid. Extracted with ethyl acetate (3×80 mL) and the combined organic phases were washed with water (1×20 mL), dried over anhydrous MgSO4, filtered and evaporated in vacuo which gave (±)N-CBZ-1-amino-2-phenylethyl phosphonous acid (20) (15.44 g).

1. additionThe pH of the solution during this addition
2. concentrationwas concentrated in vacuo to half volume
3. washWashed with diethyl ether (2×75 mL)
4. additionacidified to pH1 with the addition of concentrated aqueous hydrochloric acid
5. extractionExtracted with ethyl acetate (3×80 mL)
6. washthe combined organic phases were washed with water (1×20 mL)
7. dry with materialdried over anhydrous MgSO4
8. filtrationfiltered
9. customevaporated in vacuo which