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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1017129Generated: October 30, 2026

Dichloromethane → 5-Nitroquinoline-8-carbonitrile

https://huagongshe.com/reaction/1017129

Reaction equation

Participants

RoleNameHCIDCharge
ReactantDichloromethaneHCID 6344—
Reactant8-Bromo-5-nitroquinolineHCID 15709182—
ReactantHCID 178418546HCID 178418546—
SolventDimethylformamideHCID 6228—
Product5-Nitroquinoline-8-carbonitrileHCID 21874838—

Reaction Steps

5.80 g of 8-bromo-5-nitroquinoline and 2.00 g of copper(I) cyanide in 15 ml of dimethylformamide were heated to 150° C. for 5 hours. After cooling, methylene chloride was added, insoluble particles were filtered off and the filtrate was concentrated.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS06479436B1
Source datasetuspto-grants-2002_11
ORD IDord-ebeb0dde833d40a392569d5f2846d030
Source noteuspto-grants-2002_11