8-Methylquinoline-5-carboxylic acid → 8-Methyl-1,2,3,4-tetrahydroquinoline-5-carboxylic acid

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Reaction Steps

0.1 mol of 8-methylquinoline-5-carboxylic acid was suspended in 1.5 1 of ethanol and admixed with 10.0 g of palladium on activated carbon (5%). In an autoclave, the mixture was reduced at 50° C. with hydrogen (1 bar) over a period of 48 hours (HPLC monitoring). The reaction mixture was subsequently filtered, the filter cake was washed with ethanol and the combined organic filtrates were concentrated.

Provenance & Evidence