反应详情

3,5-Di-t-butylbenzoic acid, purchased from Aldrich Chemical Co., (10 g, 0.042 mol) was dissolved in 50 mL thionyl chloride and the light yellow solution was refluxed for 3 h under argon. The reaction was cooled to room temperature and excess SOCl2 was evaporated under vacuum (liq. N2 trap). The resulting oil was dissolved in dry toluene (100 mL) and the resulting solution was evaporated under vacuum to give the 3,5-di-t-butylbenzoyl chloride as a light brown oil (10.5 g, 99%).

1. temperaturethe light yellow solution was refluxed for 3 h under argon
2. customexcess SOCl2 was evaporated under vacuum (liq. N2 trap)
3. dissolutionThe resulting oil was dissolved in dry toluene (100 mL)
4. customthe resulting solution was evaporated under vacuum