2-Chloro-3-(trifluoromethyl)pyridine → 2-[4-Chloro-2-fluoro-5-(3-trifluoromethyl-2-pyridyloxy)phenyl]-6,7-dihydropyrrolo[1,2-c]pyrimidine-1,3(2H,5H)-dione

Participants

Role	Name	HCID	Charge
Reactant	2-Chloro-3-(trifluoromethyl)pyridine	HCID 589833	—
Reactant	2-(4-Chloro-2-fluoro-5-hydroxyphenyl)-6,7-dihydropyrrolo[1,2-c]pyrimidine-1,3(2H,5H)-dione	HCID 18402911	—
Reactant	2-[4-chloro-2-fluoro-5-(2-pyrimidyloxy)phenyl]hexahydro-3-thioxo-1H-[1,2,4]triazolo[1,2-a]pyridazin-1-one	HCID 18402960	—
Product	2-[4-Chloro-2-fluoro-5-(3-trifluoromethyl-2-pyridyloxy)phenyl]-6,7-dihydropyrrolo[1,2-c]pyrimidine-1,3(2H,5H)-dione	HCID 18402954	90%

Reaction Steps

This was synthesized from 2-(4-chloro-2-fluoro-5-hydroxyphenyl)-6,7-dihydro-pyrrolo-[1,2-c]pyrimidine-1,3(2H,5H)-dione and 2-chloro-3-trifluoromethylpyridine in 90% yield under similar conditions described below for the preparation of 2-[4-chloro-2-fluoro-5-(2-pyrimidyloxy)phenyl]hexahydro-3-thioxo-1H-[1,2,4]triazolo[1,2-a]pyridazin-1-one (Example 10.3) (compound (8-29).

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US06479435B1
Source dataset	uspto-grants-2002_11
ORD ID	ord-287a49306ba2436c8b31b3f7d9415549
Source note	uspto-grants-2002_11