Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Acetone | HCID 180 | — |
| Reactant | Triphosgene | HCID 94429 | — |
| Reactant | HCID 53660506 | HCID 53660506 | — |
| Solvent | Toluene | HCID 1140 | — |
| Product | HCID 178521674 | HCID 178521674 | — |
Reaction Steps
Triphosgene (0.7 g) in toluene (20 ml) was dropwise added to a solution of N-[4-chloro-2-fluoro-5-(3-trifluoromethyl-2-pyridyloxy)phenylaminothiocarbonyl]-N1-formyl-hydrazine (2.8 g) in acetone (70 ml) stirred at 0° C. Stirring was continued at room temperature for 1 hour and the solvents removed under reduced pressure. Column chromatography (methylene chloride:ethyl acetate, 3:1) yielded the product (3.3 g).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US06479435B1 |
|---|
| Source dataset | uspto-grants-2002_11 |
|---|
| ORD ID | ord-32ac8a53e1084d52ab224c1b757f2747 |
|---|
| Source note | uspto-grants-2002_11 |
|---|
