7-chloro-2-phenyl-1H-indole → HCID 70153539, compound

Participants

Reaction Steps

By substantially following the procedures of Example 1, utilising di-N-benzyloxycarbonylpiperazine-2(R)-carboxylic acid in place of N-benzyloxycarbonylnipecotic acid and 7-chloro-2-phenylindole in place of 2-phenylindole, was prepared the title compound as a white solid. (Found: C, 57.69; H, 6.11; N, 9.56; C21H24Cl3N2.0.6H2O requires C, 57.64; H, 6.27; N, 9.60%); mp 260° C. (from EtOH); [α]D22+25.2 (c 1.0 in MeOH); δH (400 MHz; D2O) 2.38 (4H, m, CH3 and aliphatic), 2.58 (3H, s, CH3), 2.70-2.88 (5H, m, aliphatics), 3.16-3.21 (2H, m, aliphatics), 3.50 (1H, m, aliphatic), 7.19 (1H, t, J 7.9 and 7.8, indole H5), 7.32 (1H, dd, J 7.6 and 0.6, indole H6), 7.51-7.55 (1H, m, aromatic), 7.57-7.63 (8H, m, aromatics); m/z (ES30) 353 (M++H, 100%).

Provenance & Evidence