HCID 18403070, compound → HCID 9903422, compound

HRID 1017202Notes

Reaction equation

HRID 1017202 reaction equation
[CH2:1]([P:5]([CH2:8][CH:9]([C:22]([O:24]CC1C=CC=CC=1)=[O:23])[CH2:10][CH2:11][C:12]([O:14]CC1C=CC=CC=1)=[O:13])(=[O:7])[OH:6])[CH2:2][CH2:3][CH3:4]>O>[CH2:1]([P:5]([CH2:8][CH:9]([CH2:10][CH2:11][C:12]([OH:14])=[O:13])[C:22]([OH:24])=[O:23])([OH:7])=[O:6])[CH2:2][CH2:3][CH3:4]

Participants

3

Reactant 1

HCID 18403070HCID 18403070, compound

Product 1

HCID 9903422HCID 9903422, compoundYield 43.3%

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

Butyl[2,4-di(benzyloxycarbonyl)butyl]phosphinic acid (2.9 g, 6.5 mmol) in 30 mL of water containing 0.32 g 10% Pd/C was hydrogenated on a Parr hydrogenator at 40 psi for 4.5 hours. The mixture was filtered through a pad of Celite and evaporated under high vacuum to give 2-[(butylhydroxyphosphinyl)methyl]pentanedioic acid (4, R=n-butyl) (0.75 g, 43%) as a clear and colorless viscous oil.

Workup

  1. filtrationThe mixture was filtered through a pad of Celite
  2. customevaporated under high vacuum

Sources & evidence

ORD record
ord-be17ab862d4f48dd8572108b45d520b7
Source dataset
uspto-grants-2002_11
Patent number
US06479471B1

Reaction notes

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