HCID 136352426, compound → HCID 135804808, compound

Participants

Reaction Steps

1-(2′,3′,5′-O-Tribenzoyl-β-L-ribofuranosyl)pyrazolo[3,4-d]pyrimidin-4(5H)-one 21 (152 mg, 0.26 mmole) was dissolved in MeOH saturated with NH3 at 0 C (75 mL). The resulting solution stood at room temperature for 24 h and concentrated. The residue was dissolved in water (30 mL), washed with EtOAc (3×15 mL). After evaporation of the water, the crystalline solid was soaked in acetonitrile (2 mL), filtered, and dried under vacuum to give 1-β-L-ribofuranosylpyrazolo[3,4-d]pyrimidin-4(5H)-one 22 as a white crystalline solid (70 mg, 99%).

Provenance & Evidence