HCID 136352428, compound → HCID 136352427, compound

Participants

Reaction Steps

3-Bromo-1-(2′,3′,5′-O-tribenzoy-β-L-ribofuranosyl)pyrazolo[3,4-d]pyrimidin-4(5H)-one 24 (280 mg, 0.43 mmole) was dissolved in MeOH saturated with NH3 at 0 C (25 mL). The solution in a sealed, stainless steel bomb was heated at 100 C for 6 h. After cooling, ammonia and methanol were evaporated. The residue was dissolved in water (40 mL), washed with EtOAc (4×20 mL), and concentrated. The residue was soaked in acetonitrile and the resulting solid filtered, dried under vacuum to give 3-Bromo-1-β-L-ribofuranosylpyrazolo[3,4-d]pyrimidin-4(5H)-one 25 as a white solid (140 mg, 95%).

Provenance & Evidence