HuagongsheHuagongshe Chemistry Print Report · For research reference only
Benzenesulfonic acid, 4-methyl-, compd. with pyridine (1:1) → [5-(Morpholin-4-ylmethyl)-4,5-dihydro-isoxazol-3-yl]methanol
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Benzenesulfonic acid, 4-methyl-, compd. with pyridine (1:1) | HCID 466102 | — |
| Reactant | [5-((Morpholin-4-yl)methyl)-4,5-dihydro-isoxazol-3-yl]methyl 2-tetrahydropyranyl ether | HCID 21978771 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | [5-(Morpholin-4-ylmethyl)-4,5-dihydro-isoxazol-3-yl]methanol | HCID 21978759 | 95% |
Reaction Steps
A mixture of [5-((morpholin-4-yl)methyl)-4,5-dihydro-isoxazol-3-yl]methyl 2-tetrahydropyranyl ether (0.63 g) with pyridinium p-toluenesulfonate (10 mol %) in methanol was heated under reflux for 24 h. After cooling to room temperature the solvent was removed in vacuo and the residue purified by flash chromatography (SiO2, CH2Cl2/MeOH/NH4OH 92/7.5/0.5) to afford [5-((morpholin-4-yl)methyl)-4,5-dihydro-isoxazol-3-yl]methanol (95%). Rf 0.17 (CH2Cl2/MeOH/NH4OH 92/7.5/0.5).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07094779B2 |
| Source dataset | uspto-grants-2006_08 |
| ORD ID | ord-d64a33a850374f16bffd91ecddd6d0c9 |
| Source note | uspto-grants-2006_08 |