反应详情

温度

0 °C

To a solution of 24.7 g (54.6 mmol) 2-(3,5-bis-trifluoromethyl-phenyl)-N-[4-(2-chloro-phenyl)-pyridin-3-yl]-N-methyl-isobutyramide in 100 ml diethyl ether were added under ice cooling 60 ml 3 N hydrochloric acid solution in diethyl ether. After stirring for 20 min at 0° C., the suspension was evaporated to dryness, re-suspended in 100 ml diethyl ether, filtered and dried in vacuo to give 26.3 g (99%) of the title compound as white crystals. M.p. 186-188° C.

1. customthe suspension was evaporated to dryness
2. filtrationfiltered
3. customdried in vacuo