HuagongsheHuagongshe Chemistry Print Report · For research reference only
Water → [5-((Morpholin-4-yl)methyl)-4,5-dihydro-isoxazol-3-yl]methanol methanesulfonate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Water | HCID 962 | — |
| Reactant | Methanesulfonyl chloride | HCID 31297 | — |
| Reactant | Diisopropylethylamine | HCID 81531 | — |
| Reactant | [5-(Morpholin-4-ylmethyl)-4,5-dihydro-isoxazol-3-yl]methanol | HCID 21978759 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | [5-((Morpholin-4-yl)methyl)-4,5-dihydro-isoxazol-3-yl]methanol methanesulfonate | HCID 21041076 | — |
Reaction Steps
To a solution of [5-(morpholin-4-ylmethyl)-4,5-dihydro-isoxazol-3-yl]methanol (0.38 g) in dichloromethane was added dropwise diisopropylethylamine (0.33 mL) and methanesulfonyl chloride (0.15 mL). The resulting solution was stirred at room temperature for 3 h and treated with water. The layers were separated and the organic layer was dried (Na2SO4) en concentrated in vacuo to afford [5-((morpholin-4-yl)methyl)-4,5-dihydro-isoxazol-3-yl]methanol methanesulfonate, 0.52 g (˜100%). Rf 0.63 (CH2Cl2/MeOH/NH4OH 92/7.5/0.5).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07094779B2 |
| Source dataset | uspto-grants-2006_08 |
| ORD ID | ord-ada8fcd0db23492da513b03733d44d67 |
| Source note | uspto-grants-2006_08 |