4,5-Dimethoxy-2-nitrobenzoic acid → 2-Amino-4,5-dimethoxybenzamide

HRID 1017510Notes

Reaction equation

HRID 1017510 reaction equation
[NH2:1][C:2]1[CH:10]=[CH:9][C:8]([O:11][CH3:12])=[CH:7][C:3]=1[C:4]([NH2:6])=[O:5].[CH3:13][O:14]C1C(OC)=CC(C(O)=O)=C([N+]([O-])=O)C=1>>[NH2:1][C:2]1[CH:10]=[C:9]([O:14][CH3:13])[C:8]([O:11][CH3:12])=[CH:7][C:3]=1[C:4]([NH2:6])=[O:5]

Participants

3

Reactant 2

HCID 786904,5-Dimethoxy-2-nitrobenzoic acidHCID 203382172-Amino-5-methoxybenzamide

Product 1

HCID 108672362-Amino-4,5-dimethoxybenzamide

Procedure

According to the preparation of 10, 4,5-dimethoxy-2-nitrobenzoic acid (5) (1.0 g, 4.4 mmol) was used to afford 11 (0.8 g) as brown powder; MS m/z 196 (M+).

Sources & evidence

ORD record
ord-ea3e402c742f45afa8389b35d58cf966
Source dataset
uspto-grants-2002_11
Patent number
US06479499B1

Reaction notes

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