反应详情

The mixture of 4,5-methylenedioxy-2-nitrobenzaldehyde (12) (1.0 g, 5.1 mmol) and Cornforth reagent (CrO3-pyridine-water) (40 ml) was stirred under reflux for 4 h, and then evaporated. The solid was dissolved in water, and acidified with 10% HCl. The acidified solution was extracted with EtOAc, and dried over MgSO4. After evaporation, the solid was treated as described for the preparation of 10 to afford 16 (0.7 g) as brown powder; MS m/z 180 (M+).

1. temperatureunder reflux for 4 h
2. customevaporated
3. dissolutionThe solid was dissolved in water
4. extractionThe acidified solution was extracted with EtOAc
5. dry with materialdried over MgSO4
6. customAfter evaporation
7. additionthe solid was treated
8. customas described for the preparation of 10