Morpholine → 2-Amino-5-(morpholin-4-yl)benzamide

HRID 1017515Notes

Reaction equation

[NH2:1][C:2]1[CH:10]=[CH:9][C:8]([N:11]([CH3:13])[CH3:12])=[CH:7][C:3]=1[C:4]([NH2:6])=[O:5].N1C[CH2:18][O:17][CH2:16]C1>>[NH2:1][C:2]1[CH:10]=[CH:9][C:8]([N:11]2[CH2:13][CH2:18][O:17][CH2:16][CH2:12]2)=[CH:7][C:3]=1[C:4]([NH2:6])=[O:5]

Participants

Reactant 2

HCID 8083Morpholine

HCID 127157972-Amino-5-(dimethylamino)benzamide

Product 1

HCID 105609362-Amino-5-(morpholin-4-yl)benzamide

Procedure

According to the preparation of compound 25, morpholine was used to afford 29 (0.8 g) as brown powder; MS m/z 221 (M+).

Sources & evidence

ORD record: ord-f206a16c10cd45d8b0887fd62ba8ffd7
Source dataset: uspto-grants-2002_11
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06479499B1

Reaction notes

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