3-Methoxybenzaldehyde → 2-(3-methoxyphenyl)quinazolin-4(3H)-one

HRID 1017518Notes

Reaction equation

HRID 1017518 reaction equation
CO[C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][C:4]=1[C:9]1[NH:18][C:17](=[O:19])[C:16]2[C:11](=[CH:12][CH:13]=[CH:14][CH:15]=2)[N:10]=1.[CH3:20][O:21]C1C=C(C=CC=1)C=O>>[CH3:20][O:21][C:6]1[CH:5]=[C:4]([C:9]2[NH:18][C:17](=[O:19])[C:16]3[C:11](=[CH:12][CH:13]=[CH:14][CH:15]=3)[N:10]=2)[CH:3]=[CH:8][CH:7]=1

Participants

3

Reactant 2

HCID 115693-MethoxybenzaldehydeHCID 1354360052-(2-methoxyphenyl)-3H-quinazolin-4-one

Product 1

HCID 1354863992-(3-methoxyphenyl)quinazolin-4(3H)-oneYield 95%

Procedure

According to the preparation of 42, 3-methoxybenzaldehyde (34) (1.0 g, 7.3 mmol) was used to afford 43 (1.7 g, 95.0%) as pale yellow needles.

Sources & evidence

ORD record
ord-d7521595276c44efba1b8769455b49e7
Source dataset
uspto-grants-2002_11
Patent number
US06479499B1

Reaction notes

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