3-Methoxybenzaldehyde → HCID 135461727, compound

HRID 1017525Notes

Reaction equation

HRID 1017525 reaction equation
COC1C=CC=CC=1C1NC(=O)C2C(=CC=CC=2)N=1.[NH2:20][C:21]1[CH:29]=[CH:28][C:27]([Cl:30])=[CH:26][C:22]=1[C:23]([NH2:25])=[O:24].[CH3:31][O:32][C:33]1[CH:34]=[C:35]([CH:38]=[CH:39][CH:40]=1)[CH:36]=O>>[CH3:31][O:32][C:33]1[CH:34]=[C:35]([C:36]2[NH:25][C:23](=[O:24])[C:22]3[C:21](=[CH:29][CH:28]=[C:27]([Cl:30])[CH:26]=3)[N:20]=2)[CH:38]=[CH:39][CH:40]=1

Participants

4

Reactant 3

HCID 115693-MethoxybenzaldehydeHCID 788762-Amino-5-chlorobenzamideHCID 1354360052-(2-methoxyphenyl)-3H-quinazolin-4-one

Product 1

HCID 135461727HCID 135461727, compoundYield 94.6%

Procedure

According to the preparation of 42, 2-amino-5-chlorobenzamide (31) (1.0 g, 5.9 mmol)and 3-methoxybenzaldehyde (34) (0.8 g, 5.9 mmol) were used to afford 50 (1.6 g, 94.3%) as pale yellow needles.

Sources & evidence

ORD record
ord-8618c3a6f4a04e348ebdd88c0fa10456
Source dataset
uspto-grants-2002_11
Patent number
US06479499B1

Reaction notes

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