3-Methoxybenzaldehyde → HCID 135422907, compound

HRID 1017527Notes

Reaction equation

HRID 1017527 reaction equation
COC1C=CC=CC=1C1NC(=O)C2C(=CC=CC=2)N=1.[NH2:20][C:21]1[CH:29]=[CH:28][C:27]([O:30][CH3:31])=[CH:26][C:22]=1[C:23]([NH2:25])=[O:24].[CH3:32][O:33][C:34]1[CH:35]=[C:36]([CH:39]=[CH:40][CH:41]=1)[CH:37]=O>>[CH3:32][O:33][C:34]1[CH:35]=[C:36]([C:37]2[NH:25][C:23](=[O:24])[C:22]3[C:21](=[CH:29][CH:28]=[C:27]([O:30][CH3:31])[CH:26]=3)[N:20]=2)[CH:39]=[CH:40][CH:41]=1

Participants

4

Reactant 3

HCID 115693-MethoxybenzaldehydeHCID 203382172-Amino-5-methoxybenzamideHCID 1354360052-(2-methoxyphenyl)-3H-quinazolin-4-one

Product 1

HCID 135422907HCID 135422907, compoundYield 42.4%

Procedure

According to the preparation of 42, 10 (1.0 g, 6.0 mmol) and 3-methoxybenzaldehyde (34) (0.8 g, 6.0 mmol) were used to afford 52 (0.7 g, 42.4%) as pale yellow needles.

Sources & evidence

ORD record
ord-4da960799251400a99f5c5949edf4cb6
Source dataset
uspto-grants-2002_11
Patent number
US06479499B1

Reaction notes

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