3-Methoxybenzaldehyde → HCID 135511100, compound

HRID 1017528Notes

Reaction equation

HRID 1017528 reaction equation
COC1C=CC=CC=1C1NC(=O)C2C(=CC=CC=2)N=1.[NH2:20][C:21]1[CH:29]=[C:28]([O:30][CH3:31])[C:27]([O:32][CH3:33])=[CH:26][C:22]=1[C:23]([NH2:25])=[O:24].[CH3:34][O:35][C:36]1[CH:37]=[C:38]([CH:41]=[CH:42][CH:43]=1)[CH:39]=O>>[CH3:34][O:35][C:36]1[CH:37]=[C:38]([C:39]2[NH:25][C:23](=[O:24])[C:22]3[C:21](=[CH:29][C:28]([O:30][CH3:31])=[C:27]([O:32][CH3:33])[CH:26]=3)[N:20]=2)[CH:41]=[CH:42][CH:43]=1

Participants

4

Reactant 3

HCID 115693-MethoxybenzaldehydeHCID 108672362-Amino-4,5-dimethoxybenzamideHCID 1354360052-(2-methoxyphenyl)-3H-quinazolin-4-one

Product 1

HCID 135511100HCID 135511100, compoundYield 31.4%

Procedure

According to the preparation of 42, 11 (1.0 g, 5.1 mmol) and 3-methoxybenzaldehyde (34) (0.7 g, 5.1 mmol) were used to afford 53 (0.5 g, 30.8%) as pale yellow prism crystals.

Sources & evidence

ORD record
ord-054fbf30555649d8baab277ef852380f
Source dataset
uspto-grants-2002_11
Patent number
US06479499B1

Reaction notes

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