3-Methoxybenzaldehyde → HCID 484124, compound

HRID 1017537Notes

Reaction equation

HRID 1017537 reaction equation
[NH2:1][C:2]1[CH:10]=[CH:9][C:8]([Cl:11])=[CH:7][C:3]=1[C:4]([NH2:6])=[O:5].[CH3:12][O:13][C:14]1[CH:15]=[C:16]([CH:19]=[CH:20][CH:21]=1)[CH:17]=O>>[CH3:12][O:13][C:14]1[CH:15]=[C:16]([C:17]2[NH:6][C:4](=[O:5])[C:3]3[C:2](=[CH:10][CH:9]=[C:8]([Cl:11])[CH:7]=3)[N:1]=2)[CH:19]=[CH:20][CH:21]=1.[CH3:12][O:13][C:14]1[CH:15]=[C:16]([CH:17]2[NH:6][C:4](=[O:5])[C:3]3[C:2](=[CH:10][CH:9]=[C:8]([Cl:11])[CH:7]=3)[NH:1]2)[CH:19]=[CH:20][CH:21]=1

Participants

4

Reactant 2

HCID 115693-MethoxybenzaldehydeHCID 788762-Amino-5-chlorobenzamide

Product 2

HCID 484124HCID 484124, compoundYield 95%HCID 135461727HCID 135461727, compoundYield 1.1%

Procedure

According to the preparation of 61 (Method B), 2-amino-5-chlorobenzamide (31) (1.0 g, 5.9 mmol) and 3-methoxybenzaldehyde (34) (0.8 g, 5.9 mmol) were used to afford 50 (20.0 mg, 1.1%) and 68 (1.6 g, 95.0%) as colorless powder.

Sources & evidence

ORD record
ord-b89b1a093ed2441ab10c588f189bf0ca
Source dataset
uspto-grants-2002_11
Patent number
US06479499B1

Reaction notes

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