Ethyl 5-bromovalerate → 4-Ethoxycarbonylbutoxy-2-phenylquinazoline

HRID 1017539Notes

Reaction equation

HRID 1017539 reaction equation
[CH3:1][O:2][C:3]1[C:12]2[C:7](=[CH:8][CH:9]=[CH:10][CH:11]=2)[N:6]=[C:5]([C:13]2[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=2)[N:4]=1.BrC[CH2:21][CH2:22][CH2:23][C:24]([O:26][CH2:27][CH3:28])=[O:25]>>[CH2:27]([O:26][C:24]([CH2:23][CH2:22][CH2:21][CH2:1][O:2][C:3]1[C:12]2[C:7](=[CH:8][CH:9]=[CH:10][CH:11]=2)[N:6]=[C:5]([C:13]2[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=2)[N:4]=1)=[O:25])[CH3:28]

Participants

3

Reactant 2

HCID 84580Ethyl 5-bromovalerateHCID 6168674-Methoxy-2-phenylquinazoline

Product 1

HCID 184039594-Ethoxycarbonylbutoxy-2-phenylquinazolineYield 79.4%

Procedure

According to the preparation of 69, ethyl 5-bromovalerate (1.88 g, 9.00 mmol) was used to yield 73 (1.25 g, 79.4%) as colorless powder.

Sources & evidence

ORD record
ord-519dabc2b03c4415b81259ce4b066e48
Source dataset
uspto-grants-2002_11
Patent number
US06479499B1

Reaction notes

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