Hydrochloric Acid → 4-(4-acetamidophenoxy)benzoic Acid

Participants

Reaction Steps

Aqueous LiOH (1M, 3.12 mL) is added to a suspension of the product of Step C (445 mg, 1.6 mmol) in dioxane (6 mL). The reaction is stirred for 90 minutes at room temperature. Concentrated HCl (1.5 mL) is added to lower the pH to less than 6 and the resulting precipitate is collected by filtration. The filter cake is washed with water then dried to give the desired product (337 mg, 80%). MS for C15H13NO4 (ESI) (M−H)− m/z 270.

Provenance & Evidence