Ether hydrochloride → HCID 22987972, compound

HRID 1017664Notes

Reaction equation

HRID 1017664 reaction equation
FC(F)(F)C(O)=O.[F:8][C:9]1[CH:14]=[CH:13][C:12]([C:15]2[C:23]3[C:18](=[N:19][CH:20]=[CH:21][N:22]=3)[NH:17][C:16]=2[C:24]2[CH:29]=[CH:28][N:27]=[C:26]([NH:30][CH2:31][CH2:32][CH2:33][OH:34])[CH:25]=2)=[CH:11][CH:10]=1.[ClH:35].C(OCC)C>>[ClH:35].[F:8][C:9]1[CH:14]=[CH:13][C:12]([C:15]2[C:23]3[C:18](=[N:19][CH:20]=[CH:21][N:22]=3)[NH:17][C:16]=2[C:24]2[CH:29]=[CH:28][N:27]=[C:26]([NH:30][CH2:31][CH2:32][CH2:33][OH:34])[CH:25]=2)=[CH:11][CH:10]=1

Participants

3

Reactant 2

HCID 10953452Ether hydrochlorideHCID 17920696HCID 17920696, compound

Product 1

HCID 22987972HCID 22987972, compound

Procedure

7-(4-Fluorophenyl)-6-[2-(3-hydroxypropylamino)pyridin-4-yl]-5H-pyrrolo-[2,3-b]pyrazine trifluoroacetate salt (0.018 g, 0.05 mmol) was treated with HCl/diethyl ether (1.0 ml of a 1.0 M solution) to give a solid. The ethereal layer was decanted off and the resulting solid was washed twice with ether. Excess ether was carefully blown off with nitrogen gas and the resulting yellow solid was dried in vacuo to 7-(4-fluorophenyl)-6-[2-(3-hydroxypropylamino)pyridin-4-yl]-5H-pyrrolo[2,3-b]pyrazine hydrochloride salt (0.019 g).

Workup

  1. customto give a solid
  2. customThe ethereal layer was decanted off
  3. washthe resulting solid was washed twice with ether
  4. dry with materialthe resulting yellow solid was dried in vacuo to 7-(4-fluorophenyl)-6-[2-(3-hydroxypropylamino)pyridin-4-yl]-5H-pyrrolo[2,3-b]pyrazine hydrochloride salt (0.019 g)

Sources & evidence

ORD record
ord-7e33f4e06ab6423aad149c05e3fedb2f
Source dataset
uspto-grants-2002_11
Patent number
US06479507B2

Reaction notes

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