化工社化工社 化学情報印刷レポート · 研究参考用
Imidazole → Ethyl 3-(tributylsilyloxy)picolinate
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Imidazole | HCID 795 | — |
| 反応物 | Water | HCID 962 | — |
| 反応物 | Tributylchlorosilane | HCID 70448 | — |
| 反応物 | Ethyl 3-hydroxypicolinate | HCID 15080989 | — |
| 溶媒 | Dichloromethane | HCID 6344 | — |
| 生成物 | Ethyl 3-(tributylsilyloxy)picolinate | HCID 22987980 | 49.7% |
反応手順
A mixture of ethyl 3-hydroxypicolinate (15 g, 900 mmol), tributylsilyl chloride (16.23 g, 110 mmol), imidazole (8.0 g, 120 mmol) in methylene chloride was stirred overnight under a nitrogen atmosphere. Water was added and the methylene chloride layer was separated and concentrated in vacuo. Purification on a silica gel column using ethyl acetate-hexane (1:4) as the eluant gave ethyl 3-(tributylsilyloxy)picolinate as a solid (20 g).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US06479507B2 |
| 出典データセット | uspto-grants-2002_11 |
| ORD ID | ord-99c87da307f14c518c593c22d41da186 |
| 出典メモ | uspto-grants-2002_11 |