Hydrochloric Acid → HCID 70163771, compound

Participants

Reaction Steps

A solution of 1-[1-(4-acetoxy-3-methoxyphenyl)ethyl]-4-(2-quinolinyl)piperazine(4.7 g) in 50% sodium hydroxide solution (8 ml) and 50% aqueous ethanol (50 ml) was heated at 50° C. for 24 hrs, under nitrogen. The reaction mixture was diluted with ethyl acetate (150 ml), neutralized with 10% hydrochloric acid and dried over anhydrous sodium sulfate, filtered, and the filtrate was concentrated in vacuo. The residue was flash chromatographed (silica gel), eluting with 1% acetone/1% methanol/dichloromethane. The appropriate fractions were collected and concentrated to afford 1.8 g (43%) of product, mp 53-54° C.

Provenance & Evidence