Hydrochloric Acid → HCID 10220475, compound

Participants

Reaction Steps

A solution of 3-nitro-6-(2-propoxyphenyl)-2(1H)-pyridinone (0.3 g) in a mixture of ethanol (20 ml) and water (10 ml) containing 2 Normal sodium hydroxide (0.75 ml) was shaken with 10% palladium on charcoal (0.05 g) under hydrogen at atmospheric pressure until the uptake of hydrogen had ceased. The filtered solution was treated with dilute hydrochloric acid to pH 6 and evaporated to half its volume. Water (5 ml) was added and the mixture was filtered to give a crude product, 0.29 g, m.p. 158°-161° C. Recrystallization from 50% aqueous ethanol afforded the pure title compound, 0.11 g, m.p. 164.5°-165.5° C.

Provenance & Evidence