Ammonia → HCID 18404757, compound

HRID 1017702Notes

Reaction equation

HRID 1017702 reaction equation
[CH3:1][C:2]1[CH:7]=[C:6]([C:8]2[CH:13]=[CH:12][CH:11]=[CH:10][C:9]=2[O:14][CH2:15][CH2:16][CH3:17])[NH:5][C:4](=[O:18])[C:3]=1[C:19]([O-:21])=O.[NH3:22]>>[CH3:1][C:2]1[CH:7]=[C:6]([C:8]2[CH:13]=[CH:12][CH:11]=[CH:10][C:9]=2[O:14][CH2:15][CH2:16][CH3:17])[NH:5][C:4](=[O:18])[C:3]=1[C:19]([NH2:22])=[O:21]

Participants

3

Reactant 2

HCID 222AmmoniaHCID 18404780HCID 18404780, compound

Product 1

HCID 18404757HCID 18404757, compound

Procedure

1,2-dihydro-4-methyl-2-oxo-6-(2-propoxyphenyl)-pyridine-3-carboxylate (0.53 g) and saturated methanolic ammonia (25 ml) was heated in a sealed vessel at 70°-85° C. for 34 hours. The residue after evaporation was triturated with methanol (10 ml) to give a solid, 0.28 g, m.p. 239°-242° C. Recrystallization from ethanol afforded the title compound, 0.18 g, m.p. 244°-246° C.

Workup

  1. customThe residue after evaporation
  2. customwas triturated with methanol (10 ml)
  3. customto give a solid, 0.28 g, m.p. 239°-242° C
  4. customRecrystallization from ethanol

Sources & evidence

ORD record
ord-91a96552425d4250b251cc6ed86e6edf
Source dataset
uspto-grants-2002_11
Patent number
US06479520B1

Reaction notes

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