3-(3-Benzyl-3H-imidazol-4-yl)-5-isobutylindan-1-one → HCID 178440602, compound

HRID 1017745Notes

Reaction equation

HRID 1017745 reaction equation
C([N:8]1[C:12]([CH:13]2[C:21]3[C:16](=[CH:17][CH:18]=[C:19]([CH2:22][CH:23]([CH3:25])[CH3:24])[CH:20]=3)[C:15](=[O:26])[CH2:14]2)=[CH:11][N:10]=[CH:9]1)C1C=CC=CC=1.[H][H]>C(O)C.[Pd]>[NH:10]1[CH:11]=[C:12]([CH:13]2[C:21]3[C:16](=[CH:17][CH:18]=[C:19]([CH2:22][CH:23]([CH3:24])[CH3:25])[CH:20]=3)[CH:15]([OH:26])[CH2:14]2)[N:8]=[CH:9]1

Participants

5

Reactant 2

HCID 184052753-(3-Benzyl-3H-imidazol-4-yl)-5-isobutylindan-1-oneHCID 178418361HCID 178418361, compound

Product 1

HCID 178440602HCID 178440602, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 702EthanolSolvent

Procedure

3-(3-Benzyl-3H-imidazol-4-yl)-5-isobutylindan-1-one (0.5 g) is dissolved in ethanol (15 ml). The reaction solution is hydrogenated at 50° C. with 10% palladium on carbon as catalyst until no more hydrogen is consumed. The mixture is filtered to remove the catalyst, and the filtrate is evaporated under reduced pressure. The crude product contains cis- and trans-isomers. The isomers are purified by flash chromatography.

Workup

  1. customis consumed
  2. filtrationThe mixture is filtered
  3. customto remove the catalyst
  4. customthe filtrate is evaporated under reduced pressure
  5. customThe isomers are purified by flash chromatography

Sources & evidence

ORD record
ord-cb2f96a074dd456e8410dfc53ae14cab
Source dataset
uspto-grants-2002_11
Patent number
US06479530B2

Reaction notes

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