Sulfuric Acid → HCID 178486418, compound

HRID 1017756Notes

Reaction equation

HRID 1017756 reaction equation
S(=O)(=O)(O)O.Cl.[CH3:7][O:8][C:9]1[CH:10]=[C:11]2[C:16](=[CH:17][CH:18]=1)[CH:15]([CH2:19][C:20]1[N:21]=[CH:22][NH:23][CH:24]=1)[CH2:14][CH2:13][CH2:12]2.[C:25](O)([CH3:28])([CH3:27])[CH3:26].[OH-].[Na+]>O>[C:25]([C:18]1[CH:17]=[C:16]2[C:11]([CH2:12][CH2:13][CH2:14][CH:15]2[CH2:19][C:20]2[N:21]=[CH:22][NH:23][CH:24]=2)=[CH:10][C:9]=1[O:8][CH3:7])([CH3:28])([CH3:27])[CH3:26]

Participants

6

Reactant 4

HCID 1118Sulfuric AcidHCID 6386tert-ButanolHCID 14798Sodium HydroxideHCID 178487148HCID 178487148, compound

Product 1

HCID 178486418HCID 178486418, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Conditions

Temperature
37.5 °C

Procedure

Sulfuric acid (0.75 ml) is added into the mixture of 4-(6-methoxy-1,2,3,4-tetrahydronaphthalen-1-ylmethyl)-1H-imidazole hydrochloride (75 mg) and tert-butanol (3 ml). The mixture is stirred at 35-40° C. for 15 hours. The reaction mixture is poured into water and is made alkaline with sodium hydroxide. The product is extracted into methylene chloride which is washed with water, dried with sodium sulfate and evaporated to dryness. The residue consisting of crude product is coverted to its hydrochloride salt in ethyl acetate. The yield is 40 mg.

Workup

  1. extractionThe product is extracted into methylene chloride which
  2. washis washed with water
  3. dry with materialdried with sodium sulfate
  4. customevaporated to dryness

Sources & evidence

ORD record
ord-b2c58e7b22e6422e983c070a489658e7
Source dataset
uspto-grants-2002_11
Patent number
US06479530B2

Reaction notes

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