反应详情

A solution of 200 mg of 1-(SR)-(3,5-bis(trifluoromethyl)phenyl)methoxy-2-(SR)-phenyl-3-(RS)-(benzyloxycarbonylamino)cyclopentane prepared in Example 4, Step B in 5 mL of methanol was hydrogenated over 50 mg of 10% Pd/C for 2 hours. The reaction was filtered and concentrated. The residue was purified on a 1 mm preparative silica gel plate eluted with 10% MeOH in ethyl acetate to obtain 120 mg of title compound. Mass spec (NH3/CI): 404 (M+1).

1. filtrationThe reaction was filtered
2. concentrationconcentrated
3. customThe residue was purified on a 1 mm preparative silica gel plate
4. washeluted with 10% MeOH in ethyl acetate