HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1017781Generated: October 27, 2026
2-Trimethylsilylthiazole → 2-(4-Bromo-2-methyl-benzoyl)-thiazole
https://huagongshe.com/reaction/1017781
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | 2-Trimethylsilylthiazole | HCID 588453 | — |
| Reactant | 4-Bromo-2-methylbenzoyl chloride | HCID 12846483 | — |
| Solvent | Ethyl Acetate | HCID 8857 | — |
| Product | 2-(4-Bromo-2-methyl-benzoyl)-thiazole | HCID 18405006 | — |
Reaction Steps
2.0 g (13 mmol) of 2-trimethylsilylthiazole and 6.1 g (26 mmol) of 4-bromo-2-methyl-benzoic acid chloride are combined while cooling with an ice bath and then are heated to 80° C. for 3 hours. The crude product is taken up in 30 ml of ethyl acetate, washed with H2O, saturated NaHCO3 solution and H2O, dried and purified by flash chromatography (silica gel; methylene chloride).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US06479524B1 |
|---|
| Source dataset | uspto-grants-2002_11 |
|---|
| ORD ID | ord-f99fb36b246243e48267fec2d2644bc8 |
|---|
| Source note | uspto-grants-2002_11 |
|---|
