Acetic Anhydride → HCID 18404845, compound

HRID 1017785Notes

Reaction equation

HRID 1017785 reaction equation
[NH2:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[NH:8][C:9]1[CH:14]=[CH:13][C:12]([Br:15])=[CH:11][C:10]=1[CH3:16].[C:17](OC(=O)C)(=O)[CH3:18]>C(O)(=O)C>[Br:15][C:12]1[CH:13]=[CH:14][C:9]([N:8]2[C:3]3[CH:4]=[CH:5][CH:6]=[CH:7][C:2]=3[N:1]=[C:17]2[CH3:18])=[C:10]([CH3:16])[CH:11]=1

Participants

4

Reactant 2

HCID 7918Acetic AnhydrideHCID 18404976HCID 18404976, compound

Product 1

HCID 18404845HCID 18404845, compound

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Procedure

A mixture of 5.22 g (18.8 mmol) of N-(2-aminophenyl)-4-bromo-2-methyl-aniline and 7.1 ml (75.2 mmol) of acetic acid anhydride is heated to boiling for 30 hours, combined with 15 ml of glacial acetic acid and heated to boiling for another 30 hours. Then the reaction mixture is concentrated and purified by flash chromatography (silica gel; methylene chloride).

Workup

  1. temperatureis heated
  2. temperatureheated
  3. waitto boiling for another 30 hours
  4. concentrationThen the reaction mixture is concentrated
  5. custompurified by flash chromatography (silica gel; methylene chloride)

Sources & evidence

ORD record
ord-6650bc2d3dba4efe8a9d1de39de56cee
Source dataset
uspto-grants-2002_11
Patent number
US06479524B1

Reaction notes

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