HuagongsheHuagongshe Chemistry Print Report · For research reference only
Propargyl alcohol → [4-(3-Hydroxy-1-propyn-1-yl)-2-methylphenyl]-4-morpholinylmethanone
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Propargyl alcohol | HCID 7859 | — |
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | HCID 18404846 | HCID 18404846 | — |
| Catalyst | Copper(1+) iodide; Copper(I) iodide; Cuprous iodide; Cuprous iodide (CuI) | HCID 24350 | — |
| Catalyst | HCID 178418397 | HCID 178418397 | — |
| Solvent | Acetonitrile | HCID 6342 | — |
| Product | [4-(3-Hydroxy-1-propyn-1-yl)-2-methylphenyl]-4-morpholinylmethanone | HCID 18404856 | — |
Reaction Steps
Prepared analogously to Example 1g from N-(4-bromo-2-methyl-benzoyl)-morpholine, propargyl alcohol, tetrakis(triphenylphosphine)palladium(0), copper(I)iodide and triethylamine in acetonitrile.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06479524B1 |
| Source dataset | uspto-grants-2002_11 |
| ORD ID | ord-1508a5b8eb9a43d9ab91d9ec514541bb |
| Source note | uspto-grants-2002_11 |