1-Methylimidazole → HCID 18405188, compound

Participants

Reaction Steps

0.82 g (10 mmol) of 1-methyl-imidazole and 2.7 g (10 mmol) of 4-iodobenzoic acid chloride are combined in 10 ml of acetonitrile while cooling with an ice bath, 1.4 ml (10 mmol) of triethylamine are added and the mixture is then stirred for 16 hours at ambient temperature. The crude product is taken up in 30 ml of ethyl acetate, washed with H2O, dried, concentrated in vacuo and purified by flash chromatography (silica gel; methylene chloride).

Provenance & Evidence