Chloroform → (-)-5,6-Dimethoxy-2-[2,2,4,6,7-pentamethyl-3-(4-ethylphenyl)-2,3-dihydro-1-benzofuran-5-yl]isoindoline hydrochloride

Participants

Role	Name	HCID	Charge
Reactant	Chloroform	HCID 6212	—
Reactant	5,6-Dimethoxy-2-[2,2,4,6,7-pentamethyl-3-(4-methylphenyl)-2,3-dihydro-1-benzofuran-5-yl]isoindoline	HCID 9911986	—
Product	(-)-5,6-Dimethoxy-2-[2,2,4,6,7-pentamethyl-3-(4-ethylphenyl)-2,3-dihydro-1-benzofuran-5-yl]isoindoline hydrochloride	HCID 21961328	61%

Reaction Steps

By using (−)-5,6-dimethoxy-2-[2,2,4,6,7-pentamethyl-3-(4-methylphenyl)-2,3-dihydro-1-benzofuran-5-yl]isoindoline, the title compound was synthesized according to Example 19a. Yield: 61%. Melting point: 173-175° C. [α]D=−44.4° (c=0.501, chloroform)

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US06479536B1
Source dataset	uspto-grants-2002_11
ORD ID	ord-38274f1abd6e4d0e9a601b10cf8082b4
Source note	uspto-grants-2002_11