N-(4-hydroxy-2,3,6-trimethylphenyl)formamide → N-[2,3,6-Trimethyl-4-[[2-methyl-3-(4-methylphenyl)-2-propenyl]oxy]phenyl]formamide

Participants

Role	Name	HCID	Charge
Reactant	N-(4-hydroxy-2,3,6-trimethylphenyl)formamide	HCID 21961295	—
Reactant	1-(3-Bromo-2-methyl-1-propenyl)-4-methylbenzene	HCID 68706538	—
Solvent	Ethyl acetate hexane	HCID 21226206	—
Product	N-[2,3,6-Trimethyl-4-[[2-methyl-3-(4-methylphenyl)-2-propenyl]oxy]phenyl]formamide	HCID 73856749	57%

Reaction Steps

By using N-(4-hydroxy-2,3,6-trimethylphenyl)formamide and 1-(3-bromo-2-methyl-1-propenyl)-4-methylbenzene, the title compound was synthesized according to Reference Example 17b. Yield: 57%. Melting point: 167-169° C. (Ethyl acetate-hexane)

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US06479536B1
Source dataset	uspto-grants-2002_11
ORD ID	ord-3ac90c74be714194b291c7356d88dc5e
Source note	uspto-grants-2002_11