4-Fluoro-N-(2,2,4,6,7-pentamethyl-3-phenyl-2,3-dihydro-1-benzofuran-5-yl)benzamide → N-(4-Fluorobenzyl)-2,2,4,6,7-pentamethyl-3-phenyl-2,3-dihydro-1-benzofuran-5-amine

HRID 1017875Notes

Reaction equation

HRID 1017875 reaction equation
[F:1][C:2]1[CH:30]=[CH:29][C:5]([C:6]([NH:8][C:9]2[C:10]([CH3:28])=[C:11]([CH3:27])[C:12]3[O:16][C:15]([CH3:18])([CH3:17])[CH:14]([C:19]4[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=4)[C:13]=3[C:25]=2[CH3:26])=O)=[CH:4][CH:3]=1>CO>[F:1][C:2]1[CH:3]=[CH:4][C:5]([CH2:6][NH:8][C:9]2[C:10]([CH3:28])=[C:11]([CH3:27])[C:12]3[O:16][C:15]([CH3:18])([CH3:17])[CH:14]([C:19]4[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=4)[C:13]=3[C:25]=2[CH3:26])=[CH:29][CH:30]=1

Participants

3

Reactant 1

HCID 102945904-Fluoro-N-(2,2,4,6,7-pentamethyl-3-phenyl-2,3-dihydro-1-benzofuran-5-yl)benzamide

Product 1

HCID 9886670N-(4-Fluorobenzyl)-2,2,4,6,7-pentamethyl-3-phenyl-2,3-dihydro-1-benzofuran-5-amineYield 60%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

By using 4-fluoro-N-(2,2,4,6,7-pentamethyl-3-phenyl-2,3-dihydro-1-benzofuran-5-yl)benzamide, the title compound was synthesized according to Example 2b. Yield: 60%. Melting point: 93-95° C. (Methanol);

Sources & evidence

ORD record
ord-7a3a914820f8494eb068ddc141a534ae
Source dataset
uspto-grants-2002_11
Patent number
US06479536B1

Reaction notes

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