4-Fluorobenzoyl chloride → HCID 10273713, compound

HRID 1017895Notes

Reaction equation

HRID 1017895 reaction equation
[F:1][C:2]1[CH:7]=[CH:6][C:5]([CH:8]2[C:12]3[C:13]([CH3:20])=[C:14]([NH2:19])[C:15]([CH3:18])=[C:16]([CH3:17])[C:11]=3[O:10][C:9]2([CH3:22])[CH3:21])=[CH:4][CH:3]=1.[F:23][C:24]1[CH:32]=[CH:31][C:27]([C:28](Cl)=[O:29])=[CH:26][CH:25]=1>C(OCC)(=O)C.CCCCCC>[F:23][C:24]1[CH:32]=[CH:31][C:27]([C:28]([NH:19][C:14]2[C:15]([CH3:18])=[C:16]([CH3:17])[C:11]3[O:10][C:9]([CH3:22])([CH3:21])[CH:8]([C:5]4[CH:6]=[CH:7][C:2]([F:1])=[CH:3][CH:4]=4)[C:12]=3[C:13]=2[CH3:20])=[O:29])=[CH:26][CH:25]=1

Participants

4

Reactant 2

HCID 678794-Fluorobenzoyl chlorideHCID 10828013HCID 10828013, compound

Product 1

HCID 10273713HCID 10273713, compoundYield 75%

Reagents, catalysts & solvents 1

HCID 21226206Ethyl acetate hexaneSolvent

Procedure

By using 3-(4-fluorophenyl)-2,2,4,6,7-pentamethyl-2,3-dihydro-1-benzofuran-5-amine and 4-fluorobenzoyl chloride, the title compound was synthesized according to Example 1b. Yield: 75%. Melting point: 140-142° C. (Ethyl acetate-hexane)

Sources & evidence

ORD record
ord-5fab39e9bc414093aa6368a0ea81ba44
Source dataset
uspto-grants-2002_11
Patent number
US06479536B1

Reaction notes

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