4-Fluorobenzoyl chloride → HCID 10224565, compound

HRID 1017908Notes

Reaction equation

HRID 1017908 reaction equation
[CH:1]([C:4]1[CH:9]=[CH:8][C:7]([C:10]2[C:14]3[C:15]([CH3:22])=[C:16]([NH2:21])[C:17]([CH3:20])=[C:18]([CH3:19])[C:13]=3[O:12][C:11]=2[CH3:23])=[CH:6][CH:5]=1)([CH3:3])[CH3:2].[F:24][C:25]1[CH:33]=[CH:32][C:28]([C:29](Cl)=[O:30])=[CH:27][CH:26]=1>C(OCC)(=O)C.CCCCCC>[F:24][C:25]1[CH:33]=[CH:32][C:28]([C:29]([NH:21][C:16]2[C:17]([CH3:20])=[C:18]([CH3:19])[C:13]3[O:12][C:11]([CH3:23])=[C:10]([C:7]4[CH:8]=[CH:9][C:4]([CH:1]([CH3:3])[CH3:2])=[CH:5][CH:6]=4)[C:14]=3[C:15]=2[CH3:22])=[O:30])=[CH:27][CH:26]=1

Participants

4

Reactant 2

HCID 678794-Fluorobenzoyl chlorideHCID 68706510HCID 68706510, compound

Product 1

HCID 10224565HCID 10224565, compoundYield 72%

Reagents, catalysts & solvents 1

HCID 21226206Ethyl acetate hexaneSolvent

Procedure

By using 3-(4-isopropylphenyl)-2,4,6,7-tetramethyl-1-benzofuran-5-amine and 4-fluorobenzoyl chloride, the title compound was synthesized according to Example 1b. Yield: 72%. Melting point: 242-245° C. (Ethyl acetate-hexane)

Sources & evidence

ORD record
ord-0cdb0eadc8894aa4b8cf41410c731594
Source dataset
uspto-grants-2002_11
Patent number
US06479536B1

Reaction notes

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