Chloroform → 1-tert-Butyl-3-ethyl-3,5,5-trimethylpiperazin-2-one

HRID 1017964Notes

Reaction equation

[CH3:1][C:2]([NH2:10])([CH3:9])[CH2:3][NH:4][C:5]([CH3:8])([CH3:7])[CH3:6].[CH3:11][C:12]([CH2:14][CH3:15])=O.[OH-:16].[Na+].[CH:18](Cl)(Cl)Cl>>[C:5]([N:4]1[CH2:3][C:2]([CH3:9])([CH3:1])[NH:10][C:12]([CH2:14][CH3:15])([CH3:18])[C:11]1=[O:16])([CH3:8])([CH3:7])[CH3:6]

Participants

Reactant 4

HCID 6212Chloroform

HCID 6569Methyl Ethyl Ketone

HCID 14798Sodium Hydroxide

HCID 125809891,2-Propanediamine, N1-(1,1-dimethylethyl)-2-methyl-

Product 1

HCID 187604851-tert-Butyl-3-ethyl-3,5,5-trimethylpiperazin-2-oneYield 99%

Procedure

In analogy to Example B21, 1,1-dimethyl-2-t-butylaminoethylamin, methylethylketon, chloroform and NaOH are reacted to give the raw title compound (99%) as an yellow oil.

Sources & evidence

ORD record: ord-3b621466d5714f48a9c946b911c3c34f
Source dataset: uspto-grants-2002_11
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06479608B1

Reaction notes

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