Chloroform → HCID 18760547, compound

HRID 1017965Notes

Reaction equation

[CH2:1]([C:3]([NH2:11])([CH3:10])[CH2:4][NH:5][C:6]([CH3:9])([CH3:8])[CH3:7])[CH3:2].[CH3:12][C:13]([CH2:15][CH3:16])=O.[OH-:17].[Na+].[CH:19](Cl)(Cl)Cl>>[C:6]([N:5]1[CH2:12][C:13]([CH2:15][CH3:16])([CH3:19])[NH:11][C:3]([CH2:1][CH3:2])([CH3:10])[C:4]1=[O:17])([CH3:9])([CH3:8])[CH3:7]

Participants

Reactant 4

HCID 6212Chloroform

HCID 6569Methyl Ethyl Ketone

HCID 14798Sodium Hydroxide

HCID 18760475HCID 18760475, compound

Product 1

HCID 18760547HCID 18760547, compoundYield 100%

Procedure

In analogy to Example B23, 1-ethyl-1-methyl-2-t-butylaminoethylamin, methylethylketon, chloroform and NaOH are reacted to give the raw title compound (100%) as an yellow oil.

Sources & evidence

ORD record: ord-d494e9212796411481d5ac16443f079d
Source dataset: uspto-grants-2002_11
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06479608B1

Reaction notes

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