Tris(hydroxymethyl)aminomethane → HCID 69536270, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of (R)-3-benzoylamino-3-(4-{3-methoxy-4-[3-(2-methylphenyl)ureido]phenylacetyl-amino}phenyl)-propanoic acid [1.0 g, Example 5(a)], tris(hydroxymethyl)aminomethane (0.208 g), tetrahydrofuran (80 ml) and water (15 ml) was stirred at 50° C. for 1.5 hours, then cooled to room temperature and then evaporated. The residue was recrystallised from ethanol to give the title compound as a white crystalline solid (1.1 g), m.p 135-140° C. (with decomposition). [Elemental analysis:—C, 61.6; H, 6.1; N, 9.5%. Calculated for C33H32N4O6.C4H11NO3.H2O:—C, 61.75; H, 6.3; N, 9.7%].

Provenance & Evidence