Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Dimethylformamide | HCID 6228 | — |
| Reactant | 2-Chloro-5-nitropyridine | HCID 78308 | — |
| Reactant | Diisopropylethylamine | HCID 81531 | — |
| Reactant | Methyl thioacetate | HCID 519840 | — |
| Solvent | Water | HCID 962 | — |
| Product | HCID 18404587 | HCID 18404587 | 30.3% |
Reaction Steps
A mixture of methyl thioacetate (3 g), diisopropylethylamine (8.14 g), 2-chloro-5-nitropyridine (5 g) and dimethylformamide (50 ml) was heated at 80° C. for 18 hours. The reaction mixture was cooled and then poured into water (500 ml). After stirring for 1 hour at ambient temperature the mixture was filtered to give the title compound (2.03 g) as a brown solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US06479519B1 |
|---|
| Source dataset | uspto-grants-2002_11 |
|---|
| ORD ID | ord-954160bb294c4b06861d649db71e83e4 |
|---|
| Source note | uspto-grants-2002_11 |
|---|
