Phosphorus oxychloride → Pyridine-3-sulfonyl chloride

Participants

Reaction Conditions

Reaction Steps

A mixture of pyridine-3-sulphonic acid (5.0 g), phosphorous pentachloride (8.0 g), phosphorous oxychloride (30 ml) and chloroform (30 ml) was stirred at 120° C. for 18 hours. The reaction mixture was cooled to room temperature then diluted with chloroform (30 ml) and then filtered. Hydrogen chloride gas was bubbled through the filtrate for 15 minutes and the resultant precipitate collected. This material was dried in vacuo to give the title compound as a white solid.

Provenance & Evidence