Chlorosuccinimide → HCID 15817630, compound

Participants

Reaction Steps

36.6 mg (0.27 mmol) of N-chlorosuccinimide are added to a solution of 50 mg (0.14 mmol) of 2-amino-7-(2-deoxy-3,5-di-O-acetyl-β-D-erythropentofuranosyl)-4-methoxy-7H-pyrrolo[2,3-d]pyrimidine in 3 ml of dichloromethane, and the mixture is stirred at room temperature for 12 h. The solvent is stripped off and the residue is chromatographed on silica gel in CH2Cl2/acetone (9:1). 30 mg (54%) of a colorless foam are obtained from the slowly migrating main zone.

Provenance & Evidence