Acetic Acid → HCID 136342239, compound

Participants

Reaction Steps

A suspension of compound (49) (200 mg, 0.4 mmol) in 2N aq. NaOH (8 ml) is boiled under reflux for 3 h. After the solution has been neutralized with conc. AcOH, the reaction product is filtered, washed with water and dried. Colorless crystals (128 mg, 96%) are obtained after crystallizing from CH3CN. 1H-NMR ([D6] DMSO): δ=2.22 (m, Ha—C(2′)), 2.92 (m, Hβ—C(2′)), 3.52 (m, H—C(5′)), 3.72 (m, H—C(4′)), 4.33 (m, H—C(3′)), 4.81 (t, 5′-OH), 5.22 (d, 3′-OH), 6.35 (dd, H—C(1′)), 6.46 (br., NH2), 10.75 (s, NH).

Provenance & Evidence