HCID 10984692, compound → 7-DEAZA-7-IODO-2'-DEOXYGUANOSINE

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Reaction Steps

The title compound (58) is prepared in analogy with Example 51 by proceeding from compound (46) (200 mg, 0.35 mmol). Colorless crystals (126 mg, 92%) are obtained from MeCN. Melting point: 218-220° C. UV (MeOH): λmax 266 (12,000), 285 (sh, 8400). 1H-NMR ([D6] DMSO): δ=2.08 (m, Hα—C(2′)), 2.30 (m, Hβ—C(2′)), 3.48 (m, H—C(5′)), 3.74 (m, H—C(4′)), 4.26 (m, H—C(3′)), 4.89 (t, 5′-OH), 5.18 (d, 3′-OH), 6.25 (dd, H—C(1′)), 6.34 (br., NH2), 7.09 (s, H—C(6)), 10.51 (br., NH). Anal. calculated for C11H13IN4O4 (392.2): C 33.69, H 3.34, N 14.29; found: C 33.78, H 3.42, N 14.29.

Provenance & Evidence