Ethanol → 2-(4-Cyclopropanecarbonyl-phenyl)-2-methylpropionamide

HRID 1018094Notes

Reaction equation

HRID 1018094 reaction equation
[CH:1]1([C:4]([C:6]2[CH:11]=[CH:10][C:9]([C:12]([CH3:16])([CH3:15])[C:13]#[N:14])=[CH:8][CH:7]=2)=[O:5])[CH2:3][CH2:2]1.C([OH:19])C.O>[OH-].[K+]>[CH:1]1([C:4]([C:6]2[CH:7]=[CH:8][C:9]([C:12]([CH3:16])([CH3:15])[C:13]([NH2:14])=[O:19])=[CH:10][CH:11]=2)=[O:5])[CH2:2][CH2:3]1

Participants

5

Reactant 3

HCID 702EthanolHCID 962WaterHCID 234998454-(Cyclopropylcarbonyl)-alpha,alpha-dimethylbenzeneacetonitrile

Product 1

HCID 234998512-(4-Cyclopropanecarbonyl-phenyl)-2-methylpropionamide

Reagents, catalysts & solvents 1

HCID 14797Potassium HydroxideSolvent2×

Procedure

Dissolve 2-(4-cyclopropanecarbonyl-phenyl)-2-methyl-propionitrile (100 mg) in aqueous ethanolic potassium hydroxide (2 mL) (prepared from ethanol (5 mL), water (5 mL) and solid potassium hydroxide (1.5 g). Stir overnight at room temperature, then heat at reflux for 6 hours. Cool and evaporate the solvent in vacuo to give the title compound.

Workup

  1. temperatureheat
  2. temperatureat reflux for 6 hours
  3. temperatureCool
  4. customevaporate the solvent in vacuo

Sources & evidence

ORD record
ord-a7da7b7a39f04f39968e53064f462133
Source dataset
uspto-grants-2002_11
Patent number
US06479663B2

Reaction notes

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