HCID 17927434, compound → HCID 18406004, compound

HRID 1018155Notes

Reaction equation

HRID 1018155 reaction equation
C(OC(C1(CCCBr)CCC1)=O)C.C([O:16][C:17]([C:19]1([CH2:23][CH2:24][CH2:25][S:26][CH3:27])[CH2:22][CH2:21][CH2:20]1)=[O:18])C>>[CH3:27][S:26][CH2:25][CH2:24][CH2:23][C:19]1([C:17]([OH:18])=[O:16])[CH2:22][CH2:21][CH2:20]1

Participants

3

Reactant 2

HCID 17927434HCID 17927434, compoundHCID 22954338HCID 22954338, compound

Product 1

HCID 18406004HCID 18406004, compoundYield 16%

Procedure

Using the general procedure described in example 41, starting with 1-(3-bromopropyl)cyclobutanecarboxylic acid ethyl ester, 1-[3-(methylthio)propyl]cyclobutanecarboxylic acid ethyl ester was prepared in 58% yield as a colorless oil. HR MS: Obs. mass, 216.1182. Calcd. mass, 216.1184 (M+). Also, 1-[3-(methylthio)propyl]cyclobutanecarboxylic acid was obtained in 16% yield as a colorless oil. HR MS: Obs. mass, 188.0872. Calcd. mass, 188.0871 (M+).

Workup

  1. customwas prepared in 58% yield as a colorless oil

Sources & evidence

ORD record
ord-67f248d0cab34a6f8e4bcb5af849ab93
Source dataset
uspto-grants-2002_11
Patent number
US06479666B2

Reaction notes

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